Activation of human intraepithelial lymphocytes reduces CD3 expression
نویسندگان
چکیده
منابع مشابه
Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?
BACKGROUND Activation of circulating T lymphocytes results in expression of HLA-DR, interleukin-2 receptor (IL-2R), transferrin receptor (TrR), and decreased amounts of surface CD3. AIM To examine the activation status of human intestinal intraepithelial lymphocytes (IELs) by flow cytometry. PATIENTS AND METHODS Duodenal biopsy specimens from 12 patients provided a source of intestinal lymp...
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An estimate of the number of intraepithelial lymphocytes in jejunal villous epithelium can be obtained by differential counting of nuclei in the epithelium. From counts carried out in 160 jejunal biopsies from patients who did not have coeliac disease the normal range has been established as 6-40 intraepithelial lymphocytes per 100 villous epithelial cells. In some biopsies there was a moderate...
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The body's surfaces form the interface with the external environment, protecting the host. These epithelial barriers are also colonized by a controlled diversity of microorganisms, disturbances of which can give rise to disease. Specialized intraepithelial lymphocytes (IELs), which reside at these sites, are important as a first line of defense as well as in epithelial barrier organization and ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2003
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2003.02156.x